Treating Thyroid Problems In Dogs

Summary:

"A thyroid problem in a dog is usually due to a decrease or increase in the production of thyroid hormone. A decrease is referred to as hypothyroidism, while an increase is referred to as hyperthyroidism.

Hypothyroidism is thought to be genetic while hyperthyroidism is commonly caused by a thyroid tumor (carcinoma). Hyperthyroidism is extremely uncommon in dogs. Treatment for involves the removal of the diseased sections of the thyroid  in hypothyroidism and synthetic hormone replacement therapy where needed in both forms of thyroid disease.

Hypothyroidism can be easily controlled with an excellent prognosis. The prognosis for hyperthyroidism depends on the size of the thyroid tumor and if the cancer has spread. Holistic veterinarians believe natural medicine can be used to stimulate hormone production. All treatment recommendations are based on the exact condition of your dog's thyroid."

Dog Thyroid Problem
Overweight dog with long, thick and greasy coat, poor exercise tolerance, and susceptibility to skin infection diagnosed with hypothyroidism after tests came back showing low T4 and elevated TSH levels
Source: European Society of Veterinary Dermatology

Overview

The thyroid gland is found in the neck and is made up of two lobes. This gland regulates the speed at which other body processes work. The thyroid gland is part of a three gland system including the hypothalamus and the pituitary. Problems in either of these glands can negatively impact the amount of hormone released by the thyroid. Diseases such as Hypothyroidism (too little hormone) and hyperthyroidism (too much) are a direct result of this gland system not operating properly.

Dog Thyroid Anatomy
Dog Thyroid Glands and Anatomy

Dog Hypothyroidism

Dogs with this condition are suffering from the a tumor destroying the thyroid or the pituitary gland. Since hypothyroidism in dogs is related to less hormone, this directly relates to a slowing down of body systems. Specifically this means that there is a drop in production of thyroxine (T4) and 3,5,3 triiodothyronine (T3). One in 250 dogs develop the condition. The mean age is 7 years old.

Dog Comparison - Hypothyroidism
Healthy Beagle on Left Compared to Beagle Dog with Hypothyroidism on Right
Source: Oxford Labs

The disorder is referred to as being primary (caused by a problem in the thyroid gland, in a form called lymphocytic thyroiditis and Idiopathic thyroid atrophy), secondary (caused by another process in the dog such as a pituitary gland problem), or tertiary (caused by the part of the brain called the hypothalamus).

Hyperadrenocorticism and diabetes mellitus have been linked to the disease.(2)

Causes

  • Lymphocytic thyroiditis: When the thyroid is infiltrated by lymphocytes, which are small white blood cells that help the immune system function

  • Idiopathic thyroid atrophy: Where the thyroid gland wastes away with no known cause

  • Neoplasia: Cancerous tumor growth

  • Pituitary Disease: Abnormal pituitary function

  • Congenital problems

  • Iodine deficiency due to dietary problems

  • Iatrogenic: caused by a surgical procedure or radiation therapy

Breeds

Large breed dogs have a higher incidence of hypothyroidism:

  •     Doberman Pinscher
  •     Golden Retriever
  •     Labrador Retriever
  •     Cocker Spaniel
  •     German Shepherd dog
  •     Dachshund
  •     Poodle
  •     Rottweiler
  •     Spaniels
  •     Terriers
  •     Boxer
  •     Mixed breeds

Dog Thyroid Symptoms

The behavioral, gastrointestinal, cardiovascular, nervous, neuromuscular, ocular (eyes), skin and reproductive systems can be affected. Typical symptoms are:

Most Common
  • hair loss
  • weight gain
  • lethargy

Other Symptoms:

  • mental dullness
  • decrease in activity
  • weakness
  • can't keep warm
  • dry skin
  • shedding
  • dry or dull coat
  • seborrhea
  • skin infection/skin pus
  • ear canal infection (otitis externa)
  • skin thickening and puffy eyes (rare)

Rare Symptoms:

Dog Hypothyroidism Symptoms on Skin
Dog Hypothyroidism Symptoms on Skin

Symptoms are similar to euthyroid sick syndrome (normal thyroid function accompanied by abnormalities in the level of hormones in the body, usually seen in sick patients), which needs to be differentiated by hypothyroidism before a final diagnosis can be made.

Dog Hypothyroidism Symptoms
Dog Hypothyroidism Symptoms such as Weight Loss and Dull Coat

Diagnosis

Diagnosis for this type of dog thyroid problem involves measuring the amount of thyroid hormone being produced.

Treatment

Thyroid problem in dog treatment due to hypothyroidism involves replacement therapy of the hormone for the life of the patient. It may take some experimentation by your veterinarian to get the level right.  Dogs will have a normal lifespan after treatment and any symptoms should clear. Dogs will be tested for thyroid function 6 weeks after starting therapy, then every 6 to 8 weeks for 6 to 8 months, then 2x per year.

If the condition is left untreated dogs can develop myxedema (skin swelling), myxedema coma or atherosclerosis (build up of plaque in the blood vessels).

Dog Hyperthyroidism

Hyperthyroidism means that your dog is producing too much thyroid hormone. There is a higher incidence of the disease in Labrador Retrievers. The condition is usually caused by a dog thyroid tumor and is a very aggressive form of cancer, with 10% of dogs with a thyroid carnicoma being hyperthyroid (1). A form of hyperthyroidism in dogs, Iatrogenic hyperthyroidism is caused by over supplementation, but is rare.

Symptoms

This excess hormone causes the metabolism to speed up resulting in:

  • weight loss
  • desire to eat more
  • faster heart rate
  • increased urination
  • vomiting
  • diarrhea
  • shortness of breath

Diagnosis

Diagnosis is made by measuring the levels of thyroid hormone in your dog's body.

Treatment

Treatment of hyperthyroidism involves surgically removing the diseased portion of the thyroid and then using hormone replacement therapy if needed. Chemotherapy, radioactive iodine therapy are also used depending on the tumor size, how invasive it is in surrounding tissue and if it has started to metastasize or spread to other organs.

Natural Medicine

Holistic veterinarians believe that in the case of hypothyroidism, that natural medicine (herbal remedies) can be used to naturally stimulate hormone production vs. the man made synthetic kind prescribed be veterinarians. It might be worth discussing with your veterinarian alternatives such as the one made by Pet Alive called Thyro-Pet.

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References:

(1) Feldman EC, Nelson RW. Canine thyroid tumors and hyperthyroidism. In: Feldman EC, Nelson RW. Canine and Feline Endocrinology and Reproduction. St. Louis: WB Saunders, 2004, pp 219-249.

(2) Feldman EC, Nelson RW. Hypothyroidism. In: Feldman EC, Nelson RW. Canine and Feline Endocrinology and Reproduction. St. Louis: WB Saunders; 2004, pp 86-151.

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